Biochemical Characterization of a Neuroserpin Variant Associated with Hereditary Dementia
نویسندگان
چکیده
منابع مشابه
Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies.
The serpinopathies result from conformational transitions in members of the serine proteinase inhibitor superfamily with aberrant tissue deposition or loss of function. They are typified by mutants of neuroserpin that are retained within the endoplasmic reticulum of neurons as ordered polymers in association with dementia. We show here that the S49P mutant of neuroserpin that causes the dementi...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2001
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63961-2